Structural and Dynamics Analyses of β-Lactam Inhibition of Streptococcus pneumoniae Penicillin-Binding Protein 1b (PBP1b) Guide Interrogation of Structure–Activity Relationships
Abstract
The Gram-positive pathogen Streptococcus pneumoniae, like the majority of bacteria, contains a peptidoglycan-based cell wall whose structure is highly dependent on the action of penicillin-binding proteins (PBPs). While the β-lactam antibiotics have been employed as an antimicrobial strategy for nearly a century, much remains unclear about how inhibitor structure informs potency and PBP isoform selectivity. Here, we obtained high-resolution structures (
Fields of Study & Subjects
Antibiotic Resistance in Bacteria
Synthesis of β-Lactam Compounds
Computational Drug Discovery Methods
Publication details
- Journal / source
- ACS Chemical Biology
- Volume
- 21
- Issue
- 3
- Pages
- 490–501
- Publication date
- 27 January 2026
- Language
- EN