Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer’s Pathology–Attenuating Effects in In Vitro and In Vivo Models

ACS Chemical Neuroscience 2026 Open access

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Authors: Ahmet Hacımüftüoğlu, Nurullah Saraçoğlu, Sana Saffour, Nadeem Abad, Yunus Kesgun, Nadjiba Zegheb, Ersin Gundeger, Fatma Yeşilyurt, Merve Nur Ateş, Gizem Bati‐Ayaz, Öznur Altunlu, Burak Çınar
+7 more Mehmet Ali Yoruk, Ufuk Okkay, Mustafa Özkaraca, Orhan Ateş, Ali Taghizadehghalehjoughi, Ferruh Lafzi, Hasan Türkez
DOI: 10.1021/acschemneuro.5c00873
Cited by: 1
References: 94

Abstract

exerts neuroprotective effects against glutamate-induced excitotoxicity in primary hippocampal neurons while additionally modulating glutamatergic homeostasis and redox balance through functional mechanisms in astrocyte-based models, supporting its relevance as a multitarget preclinical candidate for early stage AD mechanisms.

Fields of Study & Subjects

Alzheimer's disease research and treatments Pharmacological Receptor Mechanisms and Effects Peroxisome Proliferator-Activated Receptors

Publication details

Journal / source
ACS Chemical Neuroscience
Publisher
American Chemical Society (ACS)
Volume
17
Issue
10
Pages
1919–1944
Publication date
29 April 2026
Language
EN