Tackling Sepsis Using Host Defense Peptides That Reduce Proinflammatory Cytokine Production
Abstract
Sepsis is defined as a life-threatening condition that arises when the body's dysregulated inflammatory response to infection causes injury to its own tissues and organs. Early and late mediators of sepsis are lipopolysaccharide (LPS) from bacteria and the alarmin high mobility group box 1 (HMGB1), respectively. In this Perspective, the role of host defense peptides (HDPs) in reducing proinflammatory cytokines tied to sepsis is presented. The multimodal bactericidal and immunomodulatory activities of HDPs imbue these molecules with tremendous therapeutic potential to tackle the leading cause of death worldwide.
Fields of Study & Subjects
Antimicrobial Peptides and Activities
Immune Response and Inflammation
Advanced Glycation End Products research
Publication details
- Journal / source
- ACS Infectious Diseases
- Publisher
- American Chemical Society (ACS)
- Volume
- 12
- Issue
- 3
- Pages
- 967–977
- Publication date
- 17 February 2026
- Language
- EN