A Rational Framework for Optimizing Electrochemical Biosensor Performance via Systematically Tuning Linker Length and Probe Density on a Nanobody−MXene Platform

ACS Materials Letters 2026 Open access

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Authors: Muhsin Ali, Ghanimah Abuhaimed, Raik Grünberg, Erol A. Hasan, Somayah Qutub, Mohamed Nejib Hedhili, Stefan T. Arold, Dana Alsulaiman
DOI: 10.1021/acsmaterialslett.6c00611
Cited by: 1
References: 42

Abstract

Abstract Electrochemical biosensors hold immense promise for sensitive, point-of-care detection of clinically relevant biomarkers from liquid biopsies; however, their performance is fundamentally constrained by charge screening and steric hindrance at the biointerface, particularly under physiological conditions where the Debye length is

Fields of Study & Subjects

MXene and MAX Phase Materials Advanced biosensing and bioanalysis techniques Nanopore and Nanochannel Transport Studies

Publication details

Journal / source
ACS Materials Letters
Publisher
American Chemical Society (ACS)
Volume
8
Issue
9
Pages
2721–2730
Publication date
14 August 2026
Language
EN