PROTACs for Collateral Degradation: Is It Time to Back Up the Bus?
Abstract
Off-target effects are usually undesirable in drug development, but for some PROTACs and other degraders, they may be advantageous. Specifically, this can be so when the activities of multiprotein complexes are more important than just the targeted protein of interest.
Fields of Study & Subjects
Protein Degradation and Inhibitors
Chemical Synthesis and Analysis
Ubiquitin and proteasome pathways
Publication details
- Journal / source
- ACS Medicinal Chemistry Letters
- Volume
- 17
- Issue
- 2
- Pages
- 275–279
- Publication date
- 12 January 2026
- Language
- EN