Novel Substituted Benzisoxazole Sulfonamides as Lysine Acetyl Transferase Inhibitors for the Treatment of Cancers

ACS Medicinal Chemistry Letters 2026 Open access

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Authors: Jian Rong, Steven H. Liang
DOI: 10.1021/acsmedchemlett.5c00745
Cited by: 0
References: 6

Abstract

This patent describes novel substituted benzisoxazole sulfonamides as lysine acetyl transferase (KAT) inhibitors with potential applications in cancer therapy. It provides details on the synthesis of novel substituted benzisoxazole sulfonamides, their pharmaceutical composition, and the use in the treatment of cancers.

Fields of Study & Subjects

Enzyme function and inhibition Biochemical and Molecular Research Synthesis and Catalytic Reactions

Publication details

Journal / source
ACS Medicinal Chemistry Letters
Publisher
American Chemical Society (ACS)
Volume
17
Issue
2
Pages
287–289
Publication date
2 January 2026
Language
EN