Novel Pyridopyrazine Derivatives as Inverse Agonists of the G Protein-Coupled Receptor 6

ACS Medicinal Chemistry Letters 2026 Open access

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Authors: Yinlong Li, Steven H. Liang
DOI: 10.1021/acsmedchemlett.5c00748
Cited by: 1
References: 7

Abstract

High Resolution Image Download MS PowerPoint Slide This patent highlight describes the development and evaluation of novel pyridopyrazine analogs as potent inverse agonists for G protein-coupled receptor 6 (GPR6). It discloses synthetic methods and pharmacological properties of these new GPR6 modulators.

Fields of Study & Subjects

Receptor Mechanisms and Signaling Protein Kinase Regulation and GTPase Signaling Diabetes Treatment and Management

Publication details

Journal / source
ACS Medicinal Chemistry Letters
Publisher
American Chemical Society (ACS)
Volume
17
Issue
2
Pages
280–281
Publication date
13 January 2026
Language
EN