Synthesis of Novel USP1 Inhibitors and Their Uses in Treatment of USP1 Related Diseases
Abstract
Ubiquitin-specific protease 1 (USP1) is a member of the deubiquitinating enzyme family that modulates the stability and biological activity of target proteins through the removal of ubiquitin modifications, thereby contributing to tumor development and resistance to anticancer therapies. This patent summary focuses on the design and optimization of a class of small-molecule inhibitors that exhibit high potency and selectivity toward USP1.
Fields of Study & Subjects
Ubiquitin and proteasome pathways
Protein Degradation and Inhibitors
Protease and Inhibitor Mechanisms
Publication details
- Journal / source
- ACS Medicinal Chemistry Letters
- Volume
- 17
- Issue
- 3
- Pages
- 616–618
- Publication date
- 9 February 2026
- Language
- EN