Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6 In Vivo

ACS Medicinal Chemistry Letters 2026 Open access

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Authors: Lena Ripa, Carlo Cassani, Glyn Hughes, Beatrice Ranieri, Victoria Ullah, Riccardo Zambelloni, Theresa Andreasson, Mia Collins, Botilda Lindberg, Antonio Llinàs, Rikard Pehrson, Konstantin Barylyuk
+8 more Julia Johansson, Margareta Ek, Anders Gunnarsson, Bomi Jung, Sara Lundqvist, Anna Novén, Jenny Sandmark, Annika Åstrand
DOI: 10.1021/acsmedchemlett.6c00086
Cited by: 1
References: 37

Abstract

as a potent, selective HDAC6 degrader suitable as a starting point and tool for studying HDAC6-related diseases in the lung epithelium and beyond.

Fields of Study & Subjects

Histone Deacetylase Inhibitors Research Protein Degradation and Inhibitors Peptidase Inhibition and Analysis

Publication details

Journal / source
ACS Medicinal Chemistry Letters
Publisher
American Chemical Society (ACS)
Volume
17
Issue
6
Pages
1294–1302
Publication date
1 June 2026
Language
EN