Synthesis of Novel STING Antagonists and Their Uses in Treatment of STING Related Diseases
Abstract
Stimulator of interferon genes (STING) is a transmembrane protein localized to the endoplasmic reticulum that serves as a pivotal sensor of intracellular DNA in innate immunity. Following the detection of pathogen-derived or self-derived DNA in the cytosol, STING activates signaling cascades that promote the production of type I interferons and pro-inflammatory mediators. Beyond its well-established function in host defense, STING has emerged as an important regulatory node in antitumor immune surveillance, maintenance of immune tolerance, neuroinflammatory processes, and metabolic regulation. This patent overview outlines the design, synthesis, and potential therapeutic use of newly developed compounds aimed at treating disorders associated with dysregulated STING signaling.
Fields of Study & Subjects
interferon and immune responses
Respiratory viral infections research
Virology and Viral Diseases
Publication details
- Journal / source
- ACS Medicinal Chemistry Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 17
- Issue
- 3
- Pages
- 637–639
- Publication date
- 3 March 2026
- Language
- EN