A Dual-Action Gold(I) Prodrug Targeting Redox Homeostasis and Extracellular Matrix Remodeling in Ovarian Cancer

ACS Medicinal Chemistry Letters 2026 Open access

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Authors: Riccardo Di Leo, Enrico Crispino, Lorenzo Chiaverini, Luca Famlonga, Rosamaria Militello, Tania Gamberi, Iogann Tolbatov, Alessandro Marrone, Diego La Mendola, Tiziano Marzo, Elisa Nuti
DOI: 10.1021/acsmedchemlett.6c00118
Cited by: 1
References: 41

Abstract

PAuCl alone shows no intrinsic anti-invasive effect. Computational analyses further support a structure-function relationship linking gold-ligand bonding features to the observed biological profile.

Fields of Study & Subjects

Metal complexes synthesis and properties Click Chemistry and Applications Ferrocene Chemistry and Applications

Publication details

Journal / source
ACS Medicinal Chemistry Letters
Publisher
American Chemical Society (ACS)
Volume
17
Issue
7
Pages
1555–1562
Publication date
8 June 2026
Language
EN