Novel Compounds as TREM2 Modulators for Treating Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, and Nasu-Hakola Disease

ACS Medicinal Chemistry Letters 2026 Open access

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Authors: Ram W. Sabnis, Anika R. Sabnis
DOI: 10.1021/acsmedchemlett.6c00249
Cited by: 1
References: 6

Abstract

Provided herein are novel compounds as TREM2 modulators, pharmaceutical compositions, use of such compounds in treating Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and Nasu-Hakola disease, and processes for preparing such compounds.

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Neurological Disease Mechanisms and Treatments Medicinal Plants and Neuroprotection

Publication details

Journal / source
ACS Medicinal Chemistry Letters
Publisher
American Chemical Society (ACS)
Volume
17
Issue
6
Pages
1236–1237
Publication date
21 May 2026
Language
EN