Glucose and Lactate Cooperatively Deprived by a PD-1-Presenting Nanoemulsion for Potentiated Antitumor Immunotherapy

ACS Nano 2026

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Authors: Yifan Zhang, Penghang Chen, Weihua Wen, Xiquan Qian, Ting He, Lian‐Hua Fu, Jing Lin, Peng Fei Huang
DOI: 10.1021/acsnano.5c19115
Cited by: 1
References: 49

Abstract

disrupts the redox homeostasis in tumor cells and stimulates antitumor immunity. This GLCD strategy effectively suppressed tumor growth on both unilateral and bilateral subcutaneous 4T1 breast tumor models by simultaneously impairing glycolysis and oxidative phosphorylation, enhancing antigen presentation, and promoting the infiltration of antitumor T cells. This study highlights the potent combination of glucose/lactate metabolic intervention with immunotherapy for improved antitumor treatment.

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Nanoplatforms for cancer theranostics Cancer Research and Treatments

Publication details

Journal / source
ACS Nano
Publisher
American Chemical Society (ACS)
Volume
20
Issue
25
Pages
17948–17961
Publication date
10 June 2026
Language
EN