Reactive Oxygen Species Scavenging and Thermosensitive Smart Release-Stiffening Integrated Hydrogel for Diabetic Wound Therapy

ACS Nano 2026

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Authors: Haoning Qi, Junyu Shi, Xindi Wei, Xue Jiang, Yijie Yang, Jianxu Wei, Ruiying Chen, H. Li, Hongchang Lai, Beilei Liu
DOI: 10.1021/acsnano.5c19613
Cited by: 5
References: 56

Abstract

studies confirm that TGF-β1@MATH accelerates fibroblast migration, induces myofibroblast differentiation, and modulates the immune microenvironment. In diabetic mice, TGF-β1@MATH achieves a 95% wound healing rate within 14 days, significantly enhancing re-epithelialization, collagen deposition, angiogenesis, and Tregs recruitment. This integrated design addresses multiple pathological barriers of diabetic wound areas (WA) through ROS scavenging, thermosensitive regulation and immune-modulated regeneration, offering a promising translational strategy for clinical diabetic wound management.

Fields of Study & Subjects

Wound Healing and Treatments Graphene and Nanomaterials Applications Nanoplatforms for cancer theranostics

Publication details

Journal / source
ACS Nano
Publisher
American Chemical Society (ACS)
Volume
20
Issue
7
Pages
6034–6051
Publication date
6 February 2026
Language
EN