Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

ACS Nano 2026

View at publisher
Authors: Zhengguang Wang, Qian Wang, Kaixi Liu, Xing Peng, Jiedong Wang, Shengxin Zeng, Kangchun Wang, Han Shuai, Shilong Su, J F Ye, Chaoxin Wang, Yuanyu Hu
+10 more Zeqi Ren, Caimei Wang, Xiaolin Ma, Jiajia Zheng, Yubao Lu, Peng Wen, Yufeng Zheng, Lizeng Gao, Yun Tian, Bingchuan Liu
DOI: 10.1021/acsnano.5c20068
Cited by: 1
References: 48

Abstract

Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme (ISMNzyme)-modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidase-like, and glutathione peroxidase (GSH-Px)-like activities, alongside the controlled release of Fe 2+ and polysulfides. This dual mechanism induces ferroptosis-like bacterial death while concurrently promoting angiogenesis and osteogenesis. The platform represents a promising nanozyme-based strategy for the treatment of infected bone defects.

Fields of Study & Subjects

Advanced Nanomaterials in Catalysis Nanoplatforms for cancer theranostics Polyoxometalates: Synthesis and Applications

Publication details

Journal / source
ACS Nano
Publisher
American Chemical Society (ACS)
Volume
20
Issue
9
Pages
7773–7793
Publication date
24 February 2026
Language
EN