Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy

ACS Nano 2026

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Authors: Guangyu Ma, Yuting Li, Xiang Li, Dehong Yu, Minghao Chao, Jiale Li, Jintao Guo, Kai Wang, Yang Liu, Rongrong Sun, Fenglei Gao
DOI: 10.1021/acsnano.6c00358
Cited by: 4
References: 52

Abstract

-mediated disruption of cysteine (Cys) metabolism, compromises antioxidant defenses and triggers ferroptosis. This ionic dysregulation induces tumor cell death and promotes release of damage-associated molecular patterns (DAMPs) and mitochondrial DNA (mtDNA), activating immunogenic cell death (ICD) and the cGAS-STING pathway. Resultant dendritic cell (DC) maturation and T-cell activation link ion metabolic interference to systemic immune responses. This study establishes a multi-ion metabolic intervention strategy, advancing tumor immunotherapy paradigms.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Trace Elements in Health Immune cells in cancer

Publication details

Journal / source
ACS Nano
Publisher
American Chemical Society (ACS)
Volume
20
Issue
15
Pages
11801–11821
Publication date
7 April 2026
Language
EN