Optimization of Lipid Nanoparticles for Safe and Versatile Lung-Targeted RNA Delivery and Disease Therapy

ACS Nano 2026

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Authors: Yuan Fei, Yi Lin, Peiyu Liu, Keke Zhong, Gao Y, Qiang Ma, Zhenxuan Zhou, Shenggen Luo, Rongkuan Hu, Q Cheng
DOI: 10.1021/acsnano.6c03013
Cited by: 3
References: 64

Abstract

) of approximately 0.05 mg/kg. Taken together, these findings establish Lipid-392 stLNP as a safe, efficient, and versatile platform for lung-targeted RNA delivery with broad therapeutic potential for various diseases and promising translational applications.

Fields of Study & Subjects

RNA Interference and Gene Delivery Inhalation and Respiratory Drug Delivery Nanoplatforms for cancer theranostics

Publication details

Journal / source
ACS Nano
Publisher
American Chemical Society (ACS)
Volume
20
Issue
21
Pages
15347–15362
Publication date
15 May 2026
Language
EN