A Renally Excretable Gold Nanoparticle Oncology Platform Enabling Effective Photothermal Therapy and Chemotherapy Combination

ACS Nano Medicine 2026 Open access

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Authors: Guojun Xiong, Alexandra Vaideanu, Ryan Mellor, Chengwei Jiang, Benjamin Gardner, Nick Stone, Andreas G. Schätzlein, I. F. Uchegbu
DOI: 10.1021/acsnanomed.5c00114
Cited by: 5
References: 49

Abstract

High Resolution Image Download MS PowerPoint Slide Combination therapies have largely replaced monotherapies in oncology. Thermal therapy has been developed as an adjunctive treatment owing to its safety and high compatibility with established theraypy options. However, bulky equipment and non-standardized protocols have limited its clinical use. The emergence of gold nanoparticle (AuNP)-based photothermal therapy (PTT) offers a simpler approach using injectable formulations and portable near-infrared (NIR) laser devices. However, poor excretion of AuNPs raises safety concerns and hinders translation. Here, we designed a gold nanoplatform that retains the photothermal capacity of AuNPs while enabling efficient excretion. Ultrasmall AuNPs (

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Hepatocellular Carcinoma Treatment and Prognosis Nanoparticle-Based Drug Delivery

Publication details

Journal / source
ACS Nano Medicine
Publisher
American Chemical Society (ACS)
Volume
1
Issue
2
Pages
466–481
Publication date
7 January 2026
Language
EN