Hydrosilylation of Esters via a Titanocene(III) Borohydride–PMHS System: Scope, Limitations, and Mechanistic Insights
Abstract
The hydrosilylation of aromatic and aliphatic esters using catalytic amounts of titanocene-(III) borohydride and poly-(methylhydrosiloxane) (PMHS) as the terminal reductant is described. Alcohol yields range from 43% to 99%, with select esters requiring the addition of isopropanol to promote reactivity. This modification is proposed to facilitate in situ formation of a more reactive titanocene-(III) hydride species, which appears necessary for efficient ester reduction. This ester reduction protocol is mild, cost-effective, operationally simple and has potential utility in broader reductive transformations.
Fields of Study & Subjects
Organoboron and organosilicon chemistry
Asymmetric Hydrogenation and Catalysis
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- ACS Omega
- Publisher
- American Chemical Society (ACS)
- Volume
- 11
- Issue
- 5
- Pages
- 7672–7679
- Publication date
- 25 January 2026
- Language
- EN