Function of miRNAs in Conferring Neuroprotection through a Tailored Peptide Derived from Snake Venom Nerve Growth Factor in Response to Paraquat-Induced Toxicity in Caenorhabditis elegans
Abstract
. Furthermore, we selected 31 predicted target genes from those above five upregulated miRNAs, which are involved in gene regulation, suppression of proinflammatory cytokines, mitochondrial metabolism, protein synthesis, and transmembrane transport. qRT-PCR analyses revealed a trend toward reduced expression of these targets following PQ treatment, whereas HNP pretreatment significantly restored their expression; however, NGF pretreatment did not elicit significant changes compared to the control. Comparative miRNA profiling showed that NGF/HNP restored PQ-induced alterations, with HNP enhancing alpha-synuclein clearance by significantly upregulating miR-4813-3p. These findings position HNP as a promising candidate for miRNA-targeted interventions in PD and related disorders.
Fields of Study & Subjects
Healthcare and Venom Research
Paraquat toxicity studies and treatments
Alzheimer's disease research and treatments
Publication details
- Journal / source
- ACS Omega
- Publisher
- American Chemical Society (ACS)
- Volume
- 11
- Issue
- 18
- Pages
- 26178–26194
- Publication date
- 28 April 2026
- Language
- EN