Cyclization Reaction of α-Hydroxyketones with Anthranilamides or 2-Aminobenzenesulfonamides for the Synthesis of Quinazolinones and Benzothiadiazines

ACS Omega 2026 Open access

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Authors: Ze-Xin Niu, Qing-Yang Zhang, Xin-Yi Zhao, Hui-Peng Sun, Zi-Wen Wu, Lei-Lei Chao, Wen-Yun Gao, Heng Li
DOI: 10.1021/acsomega.5c09636
Cited by: 3
References: 53

Abstract

High Resolution Image Download MS PowerPoint Slide We report in this research a novel and practical way for synthesizing quinazolin-4(3 H )-ones and the structural analogues (34 derivatives) and 1,2,4-(2 H) -benzothiadiazine-1,1-dioxides (6 derivatives) using various α-hydroxyketones and anthranilamides or 2-aminobenzenesulfonamides as substrates with yields up to 96%. The method features cheap additives (only I 2 as a catalyst or I 2 and Fe 3+ as catalysts and KMnO 4 as an oxidant), easy operation, and high atom utilization and provides a straightforward protocol for the preparation of these components of significant pharmacological potential.

Fields of Study & Subjects

Quinazolinone synthesis and applications Synthesis and biological activity Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
ACS Omega
Publisher
American Chemical Society (ACS)
Volume
11
Issue
2
Pages
3132–3149
Publication date
4 January 2026
Language
EN