New Macrocyclolipopeptides and Steroids from Mariana Trench-Derived Fungus Cladosporium sp.

ACS Omega 2026 Open access

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Authors: Qingyun Peng, Shanshan Lan, Qun Li, Yunan Liu, Wu Ruan, Kun Wu, Qianqian Shen, Yi Chen, Junfeng Wang, Dan Li, Ming-Wei Wang
DOI: 10.1021/acsomega.5c10781
Cited by: 0
References: 19

Abstract

High Resolution Image Download MS PowerPoint Slide Two unusual 13-membered macrocyclolipopeptides, cladosporiums A ( 1 ) and B ( 2 ), and four new steroids, cladosporisteroids D–G ( 3 – 6 ), were isolated from the Mariana Trench-derived fungus Cladosporium sp. RCDB004. Cladosporiums A ( 1 ) and B ( 2 ) possess an unprecedented macrocyclic skeleton formed by the condensation reaction of fatty acids and an alanine. The planar structures of isolated compounds were established by NMR and HRESIMS, with the stereochemical configurations further corroborated through X-ray crystallography. Notably, cocrystals of 1 were successfully obtained through the crystalline mate method.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Marine Sponges and Natural Products Bioactive Natural Diterpenoids Research

Publication details

Journal / source
ACS Omega
Volume
11
Issue
3
Pages
4534–4540
Publication date
12 January 2026
Language
EN