Catalyst-Controlled Regio- and Enantioselective Hydrophosphination of α,β-Unsaturated Pyridyl Ketones
Abstract
High Resolution Image Download MS PowerPoint Slide Here, we present an enantioselective and regioselective hydrophosphination of α,β-unsaturated substrates that feature both ketone and pyridine bifunctional groups. Interestingly, the activation of pyridine and ketone functionalities is selectively achieved through chiral phosphoric acid and oxazaborolidine, respectively. The regioselectivity of the phosphine nucleophiles toward the products can be well controlled by the choice of catalysts. In addition, the α-chiral phosphorus-containing pyridine products exhibit potential applications as chiral P,N -ligands.
Fields of Study & Subjects
Organophosphorus compounds synthesis
Asymmetric Synthesis and Catalysis
Phosphorus compounds and reactions
Publication details
- Journal / source
- ACS Omega
- Volume
- 11
- Issue
- 6
- Pages
- 10221–10230
- Publication date
- 6 February 2026
- Language
- EN