Electrochemically Induced Sequential Phosphorylation/Cyclization Access to Phosphorylated Pyridophenanthridines

ACS Omega 2026 Open access

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Authors: Ya’nan Ran, Miao Yu, Shengyu Cui, Jingwen Sun, Jiahui Zhang, Yangyang Hu, Yingbo Ding, Huiying Liu, Lei Liu
DOI: 10.1021/acsomega.5c12225
Cited by: 2
References: 49

Abstract

High Resolution Image Download MS PowerPoint Slide A novel electrochemical method for synthesizing phosphorylated pyrido[4,3,2-gh]phenanthridine derivatives has been developed via a cascade phosphorylation/cyclization reaction. This approach employs a Cp 2 Fe-assisted electrochemical cycle to induce phosphonyl radical addition/cyanide insertion/intramolecular cyclization, achieving target products in yields of up to 91%. The reaction features mild conditions and a broad functional group tolerance. Notably, preliminary pharmacological screening indicates that some synthesized compounds show promising inhibitory effects against selected cancer cell lines in vitro.

Fields of Study & Subjects

Radical Photochemical Reactions Organophosphorus compounds synthesis Catalytic Cross-Coupling Reactions

Publication details

Journal / source
ACS Omega
Publisher
American Chemical Society (ACS)
Volume
11
Issue
6
Pages
10603–10613
Publication date
3 February 2026
Language
EN