Antiviral Activity of Dendritic Heparan Sulfate Mimetics against Respiratory Syncytial Virus and Herpes Simplex Virus-1

ACS Omega 2026 Open access

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Authors: Yiming Yue, Amelia Chang, Sam Spijkers‐Shaw, Rory Devlin, Ye Li, Phillip M. Rendle, Ashley Nutsford, Blake Sullivan-Hill, Carol Wang, Olga V. Zubkova, Natalie E. Netzler, J K Taylor
DOI: 10.1021/acsomega.5c12846
Cited by: 1
References: 36

Abstract

and RSV-mediated membrane fusion. Additionally, we observed synergistic effects when an HS mimetic was used in combination with clinical antiviral remdesivir. The solubility, lack of anticoagulant activity, and antiviral potency of these dendritic HS mimetics make them a promising new class of broad-spectrum antiviral therapeutics.

Fields of Study & Subjects

Respiratory viral infections research Advanced Drug Delivery Systems Proteoglycans and glycosaminoglycans research

Publication details

Journal / source
ACS Omega
Publisher
American Chemical Society (ACS)
Volume
11
Issue
18
Pages
26533–26543
Publication date
30 April 2026
Language
EN