The Anticarcinogenicity Effects of Piperine and 4,5-Dihydroxypiperine in Drosophila melanogaster Somatic Cells

ACS Omega 2026 Open access

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Authors: Wellington S. Aguiar, Isabelle V. A. Pires, Lívia M. L. Barros, Pedro M. Almeida, José L. S. Sá, Benedito S. Lima-Neto, Francielle Alline Martins
DOI: 10.1021/acsomega.5c13279
Cited by: 1
References: 44

Abstract

High Resolution Image Download MS PowerPoint Slide Asymmetric dihydroxylation of piperine (PIP) was investigated under various reaction conditions. Using AD-mix-α in the presence of methanesulfonamide, the reaction yield was approximately 51% at 25 °C, whereas the reactions with RuCl 3 /NaIO 4 were less efficient. The product was purified, and its structure was determined using 1 H and 13 C NMR spectroscopy. The carcinogenicity and anticarcinogenicity of PIP and 4,5-dihydroxypiperine (dhPIP) were evaluated using the Epithelial Tumor Test (ETT) in Drosophila melanogaster and no carcinogenic activity was observed in the presence of PIP or dhPIP at 60, 120, 180, or 360 μM. Co-treatment with doxorubicin (0.4 mM) and either PIP (180 μM) or dhPIP (60 μM) inhibited tumor occurrence by 81% and 83%, respectively.

Fields of Study & Subjects

Piperaceae Chemical and Biological Studies Traditional and Medicinal Uses of Annonaceae Berberine and alkaloids research

Publication details

Journal / source
ACS Omega
Publisher
American Chemical Society (ACS)
Volume
11
Issue
14
Pages
22072–22081
Publication date
30 March 2026
Language
EN