Direct Synthesis of Protected Secondary N ‑Alkylamines via Reductive Amination of Aldehydes with Protected N ‑Alkylamines Using Me2SiHCl
Abstract
Abstract A novel protocol has been developed for the direct synthesis of protected secondary N-alkylamines through the reductive amination of aldehydes with N-protected primary N-alkylamines by using Me2SiHCl as the reducing agent. We examined the substrate generality and limitations of this method across a broad range of aldehydes, N-protecting groups, and N-alkyl substituents, and the protocol reliably furnished the corresponding protected secondary amines in moderate to excellent yields. In addition, the synthetic utility of this protocol was demonstrated through gram-scale preparation and downstream derivatization of the resulting amine products.
Fields of Study & Subjects
Advanced Synthetic Organic Chemistry
Asymmetric Hydrogenation and Catalysis
Chemical Synthesis and Reactions
Publication details
- Journal / source
- ACS Omega
- Volume
- 11
- Issue
- 9
- Pages
- 15548–15558
- Publication date
- 27 February 2026
- Language
- EN