Pd(II)-Catalyzed C–H Activation/ O -Annulation toward Succinimide-Embedded Tetracyclic Pyranonaphthoquinones and Their Application as Metal Sensors
Abstract
High Resolution Image Download MS PowerPoint Slide A Pd(II)-catalyzed cascade C–H activation/ O -annulation strategy is developed for the efficient synthesis of succinimide-integrated tetracyclic pyranonaphthoquinones using 3-aryl-2-hydroxy naphthoquinones with maleimides or itaconimides as substrates. This methodology provides a fast and efficient approach to prepare diverse tetracyclic pyranonaphthoquinones featuring spirosuccinimides or succinimide motifs via [5 + 1] cycloaddition. Notably, one of the synthesized compounds exhibited high sensitivity and selectivity as a fluorescent chemosensor for Fe 3+ ions, achieving a low detection limit of 30.07 × 10 –9 M.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Multicomponent Synthesis of Heterocycles
Bioactive Compounds and Antitumor Agents
Publication details
- Journal / source
- ACS Omega
- Publisher
- American Chemical Society (ACS)
- Volume
- 11
- Issue
- 16
- Pages
- 24822–24834
- Publication date
- 14 April 2026
- Language
- EN