Synthetic Applications of Hydroxamic Acids and Their Derivatives in Organic Chemistry
Abstract
High Resolution Image Download MS PowerPoint Slide Hydroxamic acids and their derivatives are a versatile class of organic compounds with broad utility in synthetic chemistry. This review highlights key synthetic transformations involving these molecules, covering important reactions such as their use in Weinreb amide chemistry, rearrangement processes, C–H activation directed by hydroxamate groups, their role as precursors to N -centered radicals and aza-oxyallyl cations, reduction reactions, and umpolung transformations initiated by the N–O bond cleavage.
Fields of Study & Subjects
Chemical Synthesis and Analysis
Synthesis and Reactivity of Sulfur-Containing Compounds
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- ACS Organic & Inorganic Au
- Publisher
- American Chemical Society (ACS)
- Volume
- 6
- Issue
- 2
- Pages
- 179–201
- Publication date
- 3 February 2026
- Language
- EN