Masupirdine, a Selective Serotonin 5-HT 6 Receptor Antagonist for Alzheimer’s Disease

ACS Pharmacology & Translational Science 2026 Open access

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Authors: Mireia Toledano‐Pinedo, Isabel Iriepa, M. Mercedes Rodríguez-Fernández, José Marco‐Contelles
DOI: 10.1021/acsptsci.5c00818
Cited by: 0
References: 13

Abstract

High Resolution Image Download MS PowerPoint Slide Masupirdine is an oral, small, and safe molecule, readily available by a robust, two-step synthetic scheme, showing a potent, selective serotonin 5-HT 6 receptor antagonist profile, pro-cognitive effects in various behavioral animal models in Phase 3 clinical trials for the treatment of agitation in patients with Alzheimer’s dementia.

Fields of Study & Subjects

Alzheimer's disease research and treatments Cholinesterase and Neurodegenerative Diseases Neurotransmitter Receptor Influence on Behavior

Publication details

Journal / source
ACS Pharmacology & Translational Science
Volume
9
Issue
3
Pages
761–763
Publication date
6 February 2026
Language
EN