Head-to-Head Comparison of Monomeric, Homodimeric, and Heterodimeric Fibroblast Activation Protein-Targeting Radioligands Based on Small Molecule Inhibitor and Cyclic Peptide
Abstract
In]-In-FAP-PID achieved a favorable tumor-to-background ratio and higher tumor accumulation than homodimers, suggesting the utility of the heterodimeric structure based on both small molecule FAPI and cyclic peptide for FAP-targeting radioligands in tumor imaging and therapy.
Fields of Study & Subjects
Peptidase Inhibition and Analysis
Fibroblast Growth Factor Research
Protein Kinase Regulation and GTPase Signaling
Publication details
- Journal / source
- ACS Pharmacology & Translational Science
- Publisher
- American Chemical Society (ACS)
- Volume
- 9
- Issue
- 6
- Pages
- 1531–1543
- Publication date
- 14 May 2026
- Language
- EN