A Near-Infrared Chemiluminescent Probe for Visualizing Norepinephrine in Parkinson's Disease

ACS Sensors 2026

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Authors: Zhuang Lv, J. C. Li, Pei Zhang, Zhennan Zhang, Hualong Zhou, Jiamei Liu, Yi Xue, Ling Zhang
DOI: 10.1021/acssensors.5c03087
Cited by: 2
References: 53

Abstract

Norepinephrine (NE), a key neurotransmitter, plays a crucial role in Parkinson’s disease (PD). However, precise tracking NE dynamics during PD pathology remains a significant challenge. Herein, we develop a novel near-infrared chemiluminescent probe ( CL-NE ) that can visualize the dynamic changes of NE levels in brains experiencing PD. Benefiting from its excellent sensitivity and selectivity, the CL-NE probe is applied to monitor NE dynamics in neuronal cells. Notably, CL-NE successfully observed aberrantly expressed NE in MPTP-induced Parkinson's mouse brains. Overall, our study provides a powerful tool for in vivo NE monitoring, offering valuable insights to improve the pathogenesis, diagnosis, and therapy of PD.

Fields of Study & Subjects

Molecular Sensors and Ion Detection Luminescence and Fluorescent Materials Photochromic and Fluorescence Chemistry

Publication details

Journal / source
ACS Sensors
Publisher
American Chemical Society (ACS)
Volume
11
Issue
2
Pages
1162–1171
Publication date
29 January 2026
Language
EN