Cell Membrane-Targeted Near-Infrared Fluorescent Probe for Dynamic Visualization of Brain Nitric Oxide in Epilepsy
Abstract
Nitric oxide (NO) is a key signaling molecule for oxidative stress during epilepsy, and its in situ detection in the brain is crucial. For this purpose, a panel of NO-responsive fluorescent probes ( B-NH, MB-NH, FMB-NH, TMB-NH ) was prepared based on BODIPY fluorophores in this work. By regulating the calculated log P ( c log P ), the probe MB-NH ( c log P = 2.09) was found not only to show excellent cell membrane targeting but also good blood-brain barrier (BBB) penetration ability, enabling in situ detection of NO in the brain at the cell membrane level. MB-NH exhibits high selectivity, excellent sensitivity (detection limit: 10 nM), and rapid (
Fields of Study & Subjects
Neuroscience and Neuropharmacology Research
Nitric Oxide and Endothelin Effects
Molecular Sensors and Ion Detection
Publication details
- Journal / source
- ACS Sensors
- Publisher
- American Chemical Society (ACS)
- Volume
- 11
- Issue
- 5
- Pages
- 4068–4076
- Publication date
- 17 April 2026
- Language
- EN