WebXR Stereochemistry Activity for Organic Chemistry Students

Understanding stereochemistry, particularly the R and S configuration of chiral centers, poses persistent challenges for organic chemistry students due to the abstract, particulate-level reasoning required. To address this, we developed a web-based extended reality (webXR) activity designed to improve students’ spatial reasoning and conceptual understanding of stereochemistry through immersive, interactive learning. Designed for second-year undergraduate students, the activity integrates the real-world context of glutathione to guide students through identifying chiral centers, assigning substituent priorities, rotating molecules, and determining R or S configurations. The activity includes scaffolded instruction, gamification elements, and interactive three-dimensional visualizations. A pilot implementation with 315 students in an Organic Chemistry I course included over 90% of students reporting improved visualization of 3D molecules and over 85% expressing increased confidence in assigning stereochemistry. Open-ended survey responses ( N = 310 and N = 308) further highlighted the activity’s engaging nature, while also identifying areas for improvement. This chapter highlights the use of webXR to enhance organic chemistry students’ perceived understanding of complex molecular concepts and visualization skills.