Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis

Journal of the American Chemical Society 2026

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Authors: Wenxuan Xue, Jing Jia, Mingtao Wu, Li‐Ming Yang, Rajenahally V. Jagadeesh, Professor Dr. M. Beller, Conghui Tang
DOI: 10.1021/jacs.5c12264
Cited by: 14
References: 76

Abstract

Precise control of chemo- and regioselectivity in intermolecular difunctionalization of alkenes remains a long-standing challenge in organic synthesis. Here, we report a heterogeneous cobalt single-atom-site catalyst that enables selective 1,2-sulfonamidoazidation of styrenes. The system features good functional group tolerance and excellent recyclability. By leveraging the characteristics of single-atom-site catalysis, this work provides a valuable platform for achieving highly selective, efficient, and sustainable styrene functionalization.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Sulfur-Based Synthesis Techniques Synthesis and Catalytic Reactions

Publication details

Journal / source
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Volume
148
Issue
6
Pages
5864–5872
Publication date
5 February 2026
Language
EN