Carbon-Coordinated Cobalt Electrochemical Nanoplatform Enables in Vivo Selective Monitoring of Neurochemical Dysregulation in Glioblastoma-Infiltrated Brain

Longitudinal monitoring of neurochemical dysregulation during glioblastoma (GBM) progression is essential for elucidating tumor–neuron interactions and advancing neuroprotective strategies. Current methods, however, are limited by insufficient temporal resolution, spatial precision, and operational stability in the complex tumor microenvironment. We present a microelectrode sensing platform featuring carbon-coordinated transition metal nanocatalysts (CoC x @C) for in situ, high-fidelity tracking of dopamine (DA), a key modulator of neurological function. The engineered coordination structure facilitates rapid, selective multielectron DA oxidation, while its modulated d-band center minimizes nonspecific interfacial adsorption, yielding 278-fold sensitivity and 333-fold selectivity improvements over conventional electrodes. Longitudinal DA tracking across multiple models with this platform reveals novel insights into GBM-associated neural dysfunction. This work provides the first electrochemical evidence of neurotransmitter-mediated tumor–neuron interplay and offers a robust tool for cancer neuroscience investigations and beyond.