Photodriven Enantioselective 6- endo Hydroaminative Cyclization to Chiral 4-Substituted 3,4-Dihydroisoquinolones
Abstract
A photocatalytic asymmetric protocol for the synthesis of chiral dihydroisoquinolone scaffolds, which are prevalent in natural products and pharmaceuticals, has been developed. Utilizing chiral C 2 -symmetric arylthiol as an H atom transfer catalyst, the enantioselective hydroamination-cyclization provides efficient access to a wide range of valuable 4-substituted 3,4-dihydroisoquinolones with moderate to high regio- and enantioselectivity. The synthetic utility of this methodology is demonstrated by the formal synthesis of several bioactive alkaloid intermediates.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 6
- Pages
- 6125–6134
- Publication date
- 5 February 2026
- Language
- EN