Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals

Journal of the American Chemical Society 2026 Open access

Read full text
Authors: Guillermo Gómez-Tenés, Alechania Misturini, Neyvis Almora‐Barrios, Sergio Tatay, Natalia M. Padial, Carlos Martí-Gastaldo
DOI: 10.1021/jacs.5c17377
Cited by: 0
References: 40

Abstract

Reticular frameworks are promising candidates for chiral environments, yet most rely on static stereogenic units, overlooking adaptive host-guest interactions in enantioselective recognition. We report a modular postsynthetic click strategy to install amino acid-derived peptidic moieties into UiO-68 frameworks without compromising crystallinity. Only the histidine-functionalized material exhibits high enantioselectivity for cetirizine. Simulations reveal adaptive interaction pockets, emphasizing the importance of local pore reorganization in chiral molecular recognition.

Fields of Study & Subjects

Supramolecular Self-Assembly in Materials Supramolecular Chemistry and Complexes Covalent Organic Framework Applications

Publication details

Journal / source
Journal of the American Chemical Society
Volume
148
Issue
2
Pages
2096–2102
Publication date
7 January 2026
Language
EN