Confined Chiral Pd(II) Catalyst-Enabled Enantioselective Intramolecular Aminoalkylation of Alkenes: One-Step Construction of Chiral N -Fused Bicyclic Skeletons
Abstract
Highly enantioselective intramolecular aminoalkylation of unactivated alkenes has been accomplished for the first time through the development of a novel category of confined chiral Pd(II) catalysts consisting of two axially chiral picolinic acid ligands. A variety of polycyclic compounds, featuring a saturated chiral N -fused 6/5 or 7/5 bicyclic skeleton, were synthesized in moderate to good yields with excellent enantiomeric ratios (up to 99.5:0.5) through the formation of both a C–N bond and a C–C bond in a single synthetic step.
Fields of Study & Subjects
Axial and Atropisomeric Chirality Synthesis
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 5
- Pages
- 5347–5356
- Publication date
- 26 January 2026
- Language
- EN