Decoding the Conformation of Polylactic Acid in Block Copolymer Micelles
Abstract
High Resolution Image Download MS PowerPoint Slide Understanding how molecular features dictate the self-assembly of amphiphilic block copolymers into well-defined nanostructures is essential for the rational design of advanced soft materials. However, the large number of interdependent parameters involved, such as particle size, aggregation number, interfacial curvature, and molecular weight, makes it challenging to establish general design principles. Here we establish a scaling-based framework for PEG- b -PLA micelles with a fixed hydrophilic–hydrophobic ratio. Systematic variation of molecular weights enables precise control of micelle size and aggregation number, quantified by DLS, cryo-TEM, and MALS.
Fields of Study & Subjects
Advanced Polymer Synthesis and Characterization
Block Copolymer Self-Assembly
biodegradable polymer synthesis and properties
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 5
- Pages
- 4839–4843
- Publication date
- 28 January 2026
- Language
- EN