Spatial Confinement of Platinum Nanoclusters in a Photoactive Metal–Organic Framework for Radiotherapy Enhancement and Redox-Mediated Immune Activation

Journal of the American Chemical Society 2026

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Authors: Yuxuan Xiong, J Li, Chaoyu Wang, Langston Tillman, Xiaomin Jiang, Alitza L Soiffer, R. R. Weichselbaum, Wenbin Lin
DOI: 10.1021/jacs.5c21748
Cited by: 12
References: 62

Abstract

T cell activation and infiltration and restoring responsiveness to ICB. In murine colorectal cancer and triple-negative breast cancer models, Pt/Hf-Ir-DBB combined with low-dose X-ray irradiation synergistically enhances both local tumor control and systemic antitumor immunity. These findings establish a rational strategy for overcoming metabolic and immune resistance using MOF-based multifunctional nanoradiosensitizers.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Nanocluster Synthesis and Applications Advanced Nanomaterials in Catalysis

Publication details

Journal / source
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Volume
148
Issue
6
Pages
6612–6622
Publication date
6 February 2026
Language
EN