Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity Switching

Journal of the American Chemical Society 2026

View at publisher
Authors: Zedong Zhang, Guangchun Song, Jian Shen, Jiarui Yang, Zechao Zhuang, Wenming Sun, Xiangwen Liu, D. Zhang, Dingsheng Wang, Daping He
DOI: 10.1021/jacs.5c23161
Cited by: 9
References: 57

Abstract

Inorganic nanozymes remain limited by rigid active-center structures, lacking the adaptive flexibility of natural enzymes. Here we report a flexible single-atom nanozyme (FSAzyme) enabled by regulation of Ga coordination. A dynamically reconstructing Ga–N 3 S site exhibits self-adaptive electronic modulation, allowing the FSAzyme to realize multiple enzyme-mimicking activities and versatile sensing functions. These results establish a general design strategy to introduce enzyme-like adaptivity into single-atom nanozymes.

Fields of Study & Subjects

Advanced Nanomaterials in Catalysis Nanocluster Synthesis and Applications Nanoplatforms for cancer theranostics

Publication details

Journal / source
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Volume
148
Issue
11
Pages
11455–11461
Publication date
16 March 2026
Language
EN