Total Synthesis of (±)- and (+)-Euphohyrisnoid A
Abstract
diterpenoid with a new [5-7-6-6] tetracyclic core, was accomplished. The synthesis was strategically guided by a mild intramolecular Diels-Alder (IMDA) reaction, which efficiently constructed the pivotal bicyclo[2.2.2] ring system with high diastereoselectivity. This outcome experimentally validated prior quantum mechanical calculations. The IMDA precursor was assembled efficiently via a Tsuji-Trost reaction. The desired seven stereocenters, including two quaternary stereocenters in the final product, were constructed diastereoselectively.
Fields of Study & Subjects
Bioactive Natural Diterpenoids Research
Biological Activity of Diterpenoids and Biflavonoids
Plant-based Medicinal Research
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 6
- Pages
- 5940–5945
- Publication date
- 6 February 2026
- Language
- EN