Photocatalytic Direct Deoxytrifluoromethoxylation of Phenols
Abstract
We developed a photoredox strategy to achieve the deoxytrifluoromethoxylation of phenols. This approach leverages the propensity of the OCF 3 anion to decompose into difluorophosgene, which subsequently reacts in situ with phenol to form an aryl carbonofluoridate, thereby reducing the bond energy of the Csp 2 –O bond. The use of organic photoredox catalysts enables the operation of this method under mild conditions, with simple procedures and broad applicability to various phenolic substrates, and exhibits excellent selectivity among multiple C–O bonds.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Inorganic Fluorides and Related Compounds
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 8
- Pages
- 8087–8094
- Publication date
- 21 February 2026
- Language
- EN