Asymmetric Total Synthesis and Structure Revision of (+)-Mangicol D
Abstract
High Resolution Image Download MS PowerPoint Slide Isolated from the marine fungus Fusarium heterosporum, mangicols represent a new class of sesterterpenoids featuring unprecedented spirotetracyclic cores and notable bioactivities. Herein, we report the first asymmetric synthesis of a mangicol sesterterpene exploiting a domino carbopalladation-carbonylation, Conia-ene cyclization, and SmI 2 -mediated reductive cyclization to establish the spiro-fused tetracyclic framework in a concise manner. Our findings suggest a stereochemical revision of the polyol side chain of the initially isolated mangicols.
Fields of Study & Subjects
Natural Compound Pharmacology Studies
Microbial Natural Products and Biosynthesis
Synthetic Organic Chemistry Methods
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 14
- Pages
- 14721–14725
- Publication date
- 2 April 2026
- Language
- EN