Peptidic Catalysts Conformationally Tuned for Fluoride Binding and Delivery
Abstract
High Resolution Image Download MS PowerPoint Slide Knowledge on how fluoride interacts with peptides is currently limited to in silico studies. Here, we report an experimental investigation on the ability of peptidic scaffolds to bind fluoride using TBAF·3H 2 O or CsF. For CsF, in-depth NMR and GOAT-DFT studies shed light on peptides acting as chelators to both fluoride and cesium ions. This finding led to the development of the first peptide-catalyzed fluorination reactions. These advances open a new avenue to investigate fluorination chemistry with peptide-based catalysts that are considered as the possible ancestors to enzymes.
Fields of Study & Subjects
Supramolecular Self-Assembly in Materials
Fluorine in Organic Chemistry
Chemical Synthesis and Analysis
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 9
- Pages
- 9238–9243
- Publication date
- 24 February 2026
- Language
- EN