Tailored Manganese-Catalyzed Enantioconvergent Hydrophosphination to Access Remote P , C -Stereogenic Phosphines
Abstract
Achieving stereocontrol over two remote, flexible P - and C -stereocenters with a single catalyst remains a formidable challenge in the construction of chiral phosphines. We herein report a manganese-catalyzed enantioconvergent hydrophosphination of racemic allylic alcohols via a borrowing hydrogen (BH) strategy. This approach utilizes a single tailored Mn catalyst to orchestrate a cascade of dehydrogenation, enantioconvergent P–H addition, and asymmetric hydrogenation. This method provides direct access to P,C -stereogenic γ -hydroxy phosphines with excellent enantio- and diastereoselectivity, offering an atom-economical and sustainable route to diverse, high-value chiral phosphine libraries.
Fields of Study & Subjects
Asymmetric Hydrogenation and Catalysis
Organoboron and organosilicon chemistry
Organophosphorus compounds synthesis
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 13
- Pages
- 14535–14545
- Publication date
- 27 March 2026
- Language
- EN