Photoelectrochemical Valorization of Nitromethane for Oxime Synthesis
Abstract
The catalytic upgrading of bulk feedstock chemicals into value-added products represents a powerful approach in modern chemical synthesis. Herein, we describe an iron-catalyzed photoelectrochemical strategy that enables the efficient conversion of nitromethane (MeNO 2 ), an abundant industrial feedstock, into synthetically valuable nitric oxide (·NO). This proof-of-concept platform allows the direct synthesis of structurally diverse oximes from MeNO 2 and alcohols and exhibits broad functional group tolerance, including compatibility with carbonyl groups and acid-sensitive motifs such as esters and silyl ethers. Mechanistic investigations reveal that the iron catalyst plays a dual role: promoting radical deformylation of alcohols or ring-opening of cycloalkanols and mediating the conversion of MeNO 2 into ·NO.
Fields of Study & Subjects
Chemical Synthesis and Reactions
Nanomaterials for catalytic reactions
Environmental remediation with nanomaterials
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 12
- Pages
- 12513–12519
- Publication date
- 19 March 2026
- Language
- EN