Polymerization-Induced Functional Switching of Engineered Polyhydroxyalkanoate Synthase Directs Block Copolymerization

Journal of the American Chemical Society 2026

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Authors: Kengo Yanagawa, Atsuji Kodama, Hiroya Tomita, Shunsuke Kita, Shin-ichi Hachisuka, Hiroshi Kikukawa, Susumu Uchiyama, Katsumi Maenaka, Ken’ichiro Matsumoto
DOI: 10.1021/jacs.6c04919
Cited by: 1
References: 69

Abstract

's conformational change, as revealed by cryo-electron microscopy. During the synthesis of the second segment, 2HB-CoA was found to inhibit 3HB-CoA polymerization, enabling the synthesis of the P(2HB) homopolymer segment in the presence of 3HB-CoA. Overall, the results demonstrated the novel sequence-regulating mechanism based on the polymerization-induced functional enhancement. The findings would be useful to further expand the structural variety of PHA for a wider range of applications.

Fields of Study & Subjects

biodegradable polymer synthesis and properties Carbon dioxide utilization in catalysis Metal-Catalyzed Oxygenation Mechanisms

Publication details

Journal / source
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Volume
148
Issue
25
Pages
26061–26075
Publication date
15 June 2026
Language
EN