High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals

Journal of the American Chemical Society 2026 Open access

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Authors: Renzhe Li, Chang Liu, Wenyuan Li, Minh Vy Truong, Seunne W. Khoo, Yunzhou Li, Rohan R. Merchant, Bryan S. Matsuura, Ho Yee Joyce Fung, Shuming Chen, Tian Qin
DOI: 10.1021/jacs.6c06952
Cited by: 4
References: 66

Abstract

Radicals with intrinsic stereogenic and radical centers offer a promising yet largely unexplored platform for synthetic chemistry. We reported a family of chiral sulfonimidoyl radicals that enable stereoretentive radical transfer by using our bench-stable reagents. This approach unlocked switchable, modular access to enantioenriched sulfoximines or sulfinamides, avoiding the use of strong oxidants and organometallic nucleophiles. Additionally, mechanistic studies and computational investigations provide insightful and plausible explanations for the observed high fidelity of these underexplored chiral sulfonimidoyl radical species.

Fields of Study & Subjects

Radical Photochemical Reactions Synthesis and Catalytic Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Volume
148
Issue
21
Pages
21258–21265
Publication date
19 May 2026
Language
EN